Creative Diagnostics Expands Portfolio of Products for Hepatic Metabolism to Accelerate In Vitro Drug Metabolism Studies

Creative Diagnostics announces the expansion of its comprehensive range of Products for Hepatic Metabolism.

NEW YORK, NY, January 26, 2026 /24-7PressRelease/ -- Creative Diagnostics, a reagent supplier and developer focused on biologics quality control, has announced the expansion of its comprehensive range of Products for Hepatic Metabolism. This new line of liver-specific fractions, including Liver Cytosol, Liver Microsomes, and Liver S9 Fractions, comes from various species and can support pharmaceutical researchers and toxicologists in conducting critical in vitro metabolism studies.

The liver plays a central role in human metabolism, and most of its functions are performed by hepatocytes. The liver metabolizes both beneficial and harmful substances, processing endogenous and exogenous materials. The liver's primary metabolic functions fall into four categories: carbohydrate metabolism, lipid and fatty acid metabolism, protein and amino acid metabolism, and drug metabolism. Most liver diseases result in varying degrees of hepatocyte damage and functional impairment, thereby profoundly affecting metabolic processes.

The liver is the primary organ for drug metabolism and the main site of drug-induced toxicity. It accounts for over 50% of acute liver failure cases, which leads to the withdrawal or restricted use of approved medications. Beyond hepatotoxicity, metabolites generated in the liver circulate systemically to other tissues and organs, including the kidneys, heart, brain, intestines, and lungs, as well as tumors.

Harnessing drug-metabolite interactions between the liver and other organs can achieve desired therapeutic effects. However, such interactions may also lead to unintended toxic side effects. For example, the pre-chemotherapy drug ifosfamide (IFO) induces nephrotoxicity. In addition to producing the intended antitumor metabolite, 4-hydroxy-IFO, the liver generates the nephrotoxic metabolite, chloroacetaldehyde (CAA). Therefore, interactions between the liver and other organs must be carefully considered and evaluated in drug metabolism and toxicity studies.

Creative Diagnostics now offers an extensive range of hepatic metabolism related products that enable researchers to study hepatic metabolic processes with high precision and reproducibility. This new product line includes liver products from various species, such as humans, non-human primates (macaques and rhesus monkeys), dogs, rats, rabbits, and minipigs. Core products include Liver Cytosol, Liver Microsomes, and Liver S9 Fractions. Creative Diagnostics can provide comprehensive metabolic research solutions to researcher to address challenges encountered during drug development.

"Precise metabolomic analysis is the cornerstone of successful drug development," said the Creative Diagnostics project manager. "By offering a liver metabolism testing product line spanning multiple species, we help our clients in the pharmaceutical industry bridge the gap between in vitro testing and in vivo outcomes, ultimately reducing the risk of clinical failure."

Drug metabolism studies are essential and necessary during the evaluation of drugs. To learn more about the full catalog of Products for Hepatic Metabolism, or to discover innovative solutions that can accelerate research and development in the life sciences, please visit the Creative Diagnostics website at https://qbd.creative-diagnostics.com/products-for-hepatic-metabolism.html.

About Creative Diagnostics

Creative Diagnostics is a global leader in the development and manufacturing of innovative tools and reagents for bioprocess impurity analysis. The company offers a comprehensive portfolio of solutions to support researchers in the quality control of biologics and provides biopharmaceutical quality, purity and safety assays, analytical methods and applications for the biotechnology and biopharmaceutical industries.

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